سیویلیکا را در شبکه های اجتماعی دنبال نمایید.

Myelin-Oligodendrocyte Glycoprotein Antibodies Spectrum Disorders

سال انتشار: 1396
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 378

فایل این مقاله در 10 صفحه با فرمت PDF قابل دریافت می باشد

استخراج به نرم افزارهای پژوهشی:

لینک ثابت به این مقاله:

شناسه ملی سند علمی:

JR_CJNS-3-11_007

تاریخ نمایه سازی: 18 اسفند 1397

چکیده مقاله Myelin-Oligodendrocyte Glycoprotein Antibodies Spectrum Disorders

Myelin-Oligodendrocyte Glycoprotein (MOG) is an adhesive molecule responsible for myelin sheath structural integrity and maintenance. Patients with spectrum of inflammatory demyelinating disease particularly in central nervous system are reported to have antibodies against this protein. Diseases such as multiple sclerosis, clinically isolated syndrome, neuro-myelitis optica (NMO) spectrum disorders, acute disseminated encephalomyelitis, transverse myelitis and Optic neuritis seemed to have a correlation with anti-MOG antibodies. MRI findings of seropositive cases revealed spinal lesions, particularly in lower segments. For treatment of these patients methotrexate and azathioprine are suggested. Plasmaphresis and intravenous immunoglobulin may be useful too. However fingolimod and interferons can deteriorate the conditions. Finally it is concluded that anti-MOG antibodies can be a biomarker for CNS demyelinating disorders.

کلیدواژه های Myelin-Oligodendrocyte Glycoprotein Antibodies Spectrum Disorders:

نویسندگان مقاله Myelin-Oligodendrocyte Glycoprotein Antibodies Spectrum Disorders

Masoud Etemadifar

MD, Professor of Neurology, Department of Neurology, Isfahan University of Medical Science, Isfahan, Iran

Ali Fazli

MD, Department of Neurology, Isfahan University of Medical Science, Isfahan, Iran