Myelin-Oligodendrocyte Glycoprotein Antibodies Spectrum Disorders
محل انتشار: علوم اعصاب کاسپین، دوره: 3، شماره: 11
سال انتشار: 1396
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 378
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شناسه ملی سند علمی:
JR_CJNS-3-11_007
تاریخ نمایه سازی: 18 اسفند 1397
چکیده مقاله Myelin-Oligodendrocyte Glycoprotein Antibodies Spectrum Disorders
Myelin-Oligodendrocyte Glycoprotein (MOG) is an adhesive molecule responsible for myelin sheath structural integrity and maintenance. Patients with spectrum of inflammatory demyelinating disease particularly in central nervous system are reported to have antibodies against this protein. Diseases such as multiple sclerosis, clinically isolated syndrome, neuro-myelitis optica (NMO) spectrum disorders, acute disseminated encephalomyelitis, transverse myelitis and Optic neuritis seemed to have a correlation with anti-MOG antibodies. MRI findings of seropositive cases revealed spinal lesions, particularly in lower segments. For treatment of these patients methotrexate and azathioprine are suggested. Plasmaphresis and intravenous immunoglobulin may be useful too. However fingolimod and interferons can deteriorate the conditions. Finally it is concluded that anti-MOG antibodies can be a biomarker for CNS demyelinating disorders.
کلیدواژه های Myelin-Oligodendrocyte Glycoprotein Antibodies Spectrum Disorders:
نویسندگان مقاله Myelin-Oligodendrocyte Glycoprotein Antibodies Spectrum Disorders
Masoud Etemadifar
MD, Professor of Neurology, Department of Neurology, Isfahan University of Medical Science, Isfahan, Iran
Ali Fazli
MD, Department of Neurology, Isfahan University of Medical Science, Isfahan, Iran