The Effect of Neoadjuvant Radiotherapy on the Treatment of Soft Tissue Sarcoma

BackhroundsIn the last decade, limb-salvage surgery in combination with radiotherapy has increasedthe local control rate to more than %90 for soft tissue sarcoma. Given the controversysurrounding adjuvant and neo-adjuvant radiotherapy, this study seeks to compare theeffectiveness of these two methods.MethodsIn this study, 20 patients with STS undergoing neo adjuvant radiotherapy surgery wereexamined and 20 patients received radiotherapy after surgery. Shirinkage of tumor and5 years Survival and recurrence rate were assessed using Kaplan Mayer were analysis. ResultsThe mean age of patients was 15.3 ± 57.8 of whom %45.9 were female. The averagesize of tumor was 9.3 cm before neo adjuvant radiotherapy that it was decreased andpatients undergoing wide resection. The overall five-year survival rate in RT group was%74.8 before surgery and %69.3 after the surgery. The results of univariant analysisshowed that preoperative RT had a tendency to improve overall survival.ConclusionsThis paper suggested that neo-adjuvant radiotherapy could be recommended for thetreatment of soft tissue sarcomas, but further studies are needed to demonstrate itseffectiveness