Work at night and breast cancer risk
سال انتشار: 1397
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 359
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شناسه ملی سند علمی:
LAMOGMED03_107
تاریخ نمایه سازی: 21 بهمن 1397
چکیده مقاله:
Background: Working during the night is widespread and is growing in developing countries. It has been suggested that night shift work and exposure to light at night(LAN) may increase the risk of hormone dependent cancers including breast cancer.Methods:This study reviewed the latest published literatures investigated the effects of night working on the risk of breast cancer.Results: The classical risk factors for breast cancer,genetic mutations,reproductive history,obesity,alcohol,radiation and sedentary lifestyle do not explain all the potential situations of increased risk of mammary carcinogenesis.There is one environmental factor that deserves special consideration: the chronodisruption induced by exposure to LAN particularly short wavelength light(blue-light).The most widely accepted explanation for the biological effects of LAN in elevated breast cancer risk is: the light-induced inhibition of melatonin secretion,with the subsequent loss of the selective estrogen enzyme modulators and Selective estrogen receptor modulators effects of this neurohormone; and alterations to the circadian system(chronodisruption)induced by exposure to nocturnal light.Circadian rhythms(including sleep/wake cycles,body temperature,blood pressure,hormone secretion,digestion,metabolism and cell turnover)are essential for survival and driven and maintained in a hierarchi-cal manner by a central pacemaker(the biologic master clock)located in the suprachiasmatic nucleus of the hypothalamus.The disruption of the circadian rhythms induced by LAN can cause alterations in the cell cycle and lead to the development of tumors. It has been suggested that administration of the exogenous melatonin restores the decreased circulating levels of the endogenous hormone, caused by nocturnal light, and regulates the function of the circadian system.Conclusion: ≥30 years of night shift work has been suggested as a risk factor for breast cancer;however, studies are needed to assess the administration of melatonin as a chronobiotic agent to reduce the breast cancer risk in women working at night.
کلیدواژه ها:
Breast cancer-shift work-light at night-prevention
نویسندگان
Padideh Janati Ataei
Department of Midwifery and Reproductive Health , Shahid Beheshti University of Medical Sciences, Tehran, Iran