Effective Medical Treatment for Treating Symptomatic Adenomyosis

Background: Adenomyosis is a heterogeneous gynecologic condition with a range of clinical presentations, the most common being heavy menstrual bleeding and dysmenorrhea; however, patients can also be asymptomatic. Material & Methods: The aim of this review is to discuss the medical approach to the management of adenomyosis symptoms, including pain and abnormal uterine bleeding. This study was performed of a systematic literature using the keywords adenomyosis , treatment, and electronic databases PubMed, Cochrane, Embase, ProQuest and Science direct from 2010 to present.Result: The standard treatment of adenomyosis is hysterectomy, Medical therapies using suppressive hormonal treatments, such as continuous use of oral contraceptive pills, high-dose progestin, selective estrogen receptor modulators, selective progesterone receptor modulators, the levonorgestrel-releasing intrauterine device, aromatase inhibitors, danazol, and gonadotrophin receptor hormone agonists can temporarily induce regression of adenomyosis and improve the symptoms. But Microwave endometrial ablation (MEA) is a recently developed procedure that enables endometrial ablation. Oral Dienogest after the procedure has long been used to suppress endometrium development and reduce adenomyosis-related dysmenorrhea. However, some cases could be resistant to dienogest. The primary endpoints were reduction in pain recurrence and anemia. The secondary endpoint was a change in the adenomyosis lesion and its symptomatic recurrence.Conclusion: The combination of MEA and postoperative dienogest is useful for treating uterine adenomyosis with menorrhagia and dysmenorrhea.

کلیدواژه ها:

Adenomyosis ، medical treatment ، Bleeding