The Correlation of Serum C-Reactive Protein Levels and Engraftment of Autologous Hematopoietic Stem Cell

Background and Aim: Autologous hematopoietic stem cell transplantation(AHSCT) is a curative option for many hematological disorders. Earlyprediction of the engraftment is valuable since patients require extensivesupportive care during this period to prevent opportunistic infections.C-reactive protein (CRP) is a blood acute-phase protein which rises inresponse to inflammation. In this study, we evaluated the associationbetween CRP level and WBC engraftment (WE), platelet engraftment (PE)and length of hospital stay (LOHS) in AHSCT patients.Methods: 2 mL peripheral blood samples of 208 multiple myeloma (MM)and lymphoma patients candidate for AHSCT were gathered on theadmission day and the plasma CRP levels were quantified using enzymeimmunoassay. The correlation between the CRP and WE, PE and LOHSwere analyzed by Pearson correlation test and linear regression model.Results: The significant positive correlations of CRP levels were foundwith WE, PE and LOHS without considering the disease (P-value: 0.001,0.007, 0.001, respectively). Depending on the disease, only in Hodgkin’slymphoma patients (n=80), we observed a significant associationbetween CRP and WE (P: 0.001).Conclusion: Based on our data, we conclude that the plasma CRP levelson admission day correlate with some engraftment factors of AHSCTand could reflect the inflammation influencing the post-transplantationconditions. Regarding the first report of such correlation, it could give avaluable insight to clinicians about the outcome of AHSCT.

کلیدواژه ها:

C-Reactive protein ، Autologous hematopoietic stem cell transplantation