Ferulic Acid-Loaded Polyurethane for Vascular Tissue Engineering

Background and Aim: Autologous vessels have limited graft resources.Artificial vascular grafts failed in small diameter vascular graft (6 ˂mminner diameter) applications due to thrombosis, infection, lower stability,compliance mismatch, and premature occlusion. The aim of this studywas to develop scaffolds with enhanced blood compatibility and vascularcell-compatibility.Methods: In this study, polyurethane was synthesized. The synthesizedpolyurethane was blended with ferulic acid (FA) to improvehemocompatibility. Scanning electron microscopy (SEM), water contactangle (CA) measurement, and tensile test were utilized to characterizethe scaffolds. The polyurethane and polyurethane-FA scaffolds showedsuitable tensile strengths and strains.Results: The ferulic acid from the scaffolds released in a sustained manner.The polyurethane-FA scaffolds induced lower platelet adhesion with a reduction in hemolysis and fibrinogen compared to the polyurethanescaffold. The endothelial cells proliferated on the polyurethane-FAsamples. The cells expressed endothelial cell marker (CD31).Conclusion: Therefore, the new polyurethane modified with ferulic acidcan be considered as a promising candidate for the vascular application.

کلیدواژه ها:

Polyurethane ، Ferulic acid ، Hemocompatibility