Association Between Body Mass Index and Outcomes of Allogeneic Hematopoietic Stem Cell Transplantation

سال انتشار: 1397
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 441

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شناسه ملی سند علمی:

NSCMRMED03_128

تاریخ نمایه سازی: 30 دی 1397

چکیده مقاله:

Background and Aim: Hematopoietic stem cell transplantation (HSCT) is an effective treatment for hematological malignancies. A variety of riskfactors such as disease stage, stem cell source, and HLA mismatch havebeen shown to affect the outcome of HSCT. Pre-transplantation, bodymass index (BMI) has also been considered as a risk-factor for allogeneic-HSCT and may influence stem cell mobilization and outcomes aftertransplantation such as graft-versus-host disease (GvHD) incidence andsurvival. The purpose of this study was to assess the association of BMIwith allo-HSCT outcomes and stem cell mobilization.Methods: In this retrospective study, since 2008, 196 patients withhematologic malignancies including 102 acute myeloid leukemia, 53acute lymphocytic leukemia, 10 non-Hodgkin lymphoma, 12 Hodgkinlymphoma, and 7 aplastic anemia, were treated with allo-HSCT inTaleghani hematopoietic stem cell transplantation center. The correlationbetween BMI and GvHD incidence, survival, CD34 and mononuclearcells (MNCs) of patients was evaluated. Student T-test and linearregression tests, Kaplan-Meier and Cox Regression tests and Spearman sRho test were used to assess the correlation of BMI with GvHD incidence,survival, and mobilization variables respectively.Results: From a total of 196 patients, 11.2% were underweight, 48.3%were normal weight and 42.3% were overweight. There was a staticallysignificant correlation between BMI in underweight patients and GvHDincidence (P value = 0.001) and between BMI in overweight patientsand survival (P value = 0.01) and MNCs (P value = 0.009) in allogeneictransplanted patients. But there was not a significant difference betweenBMI in underweight and normal weight patients and survival (P value= 0.06). Moreover, there was no significant difference between BMI inoverweight, underweight and normal patients and CD34 (P value = 0.8).Conclusion: Our data suggest Lower BMI is associated with higherGVHD incidence, lower MNCs and mobilization, and lower survival rate.Therefore, higher BMI is associated with better allogeneic transplantationoutcome and stem cell mobilization in leukemic patients. It can beconcluded that BMI is a useful prognostic factor in patients before andafter transplantation. But further studies are required to confirm theimpact of BMI on CD34 stem cells.

کلیدواژه ها:

GVHD ، Body Mass Index ، Hematopoietic stem cell transplantation ، Survival

نویسندگان

Mahshid Mehdizadeh

Hematopoietic Stem Cell Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Elham Roshandel

Hematopoietic Stem Cell Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Mohammad Hossein Mohammadi

Hematopoietic Stem Cell Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Ghazaleh Sankanian

Hematopoietic Stem Cell Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran