Vitamin D and Autoimmunity, The case of Juvenile Idiopathic Arthritis

سال انتشار: 1397
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 255

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شناسه ملی سند علمی:

INC15_679

تاریخ نمایه سازی: 30 دی 1397

چکیده مقاله:

Recently the roles of vitamin D in metabolism and signaling for both innate immune and adaptive immune response have been reported. Link between other autoimmune disease and lower levels of vitamin D established. Studies indicate suboptimal vitamin D status in children with Juvenile Idiopathic Arthritis (JIA). However, less it is known about the association between vitamin D and as one of the most common chronic childhood diseases.We used data from the Biologically-based Outcome Predictors (BBOP) in JIA a prospective longitudinal multicentre study in Canada to evaluate the potential association between vitamin D and disease activities considering probable environmental and genetic factors.In this lecture, I will provide an overview of the existing literature, including data from our own research, about the association between vitamin D and JIA. Also, I will discuss the gaps in research and potential mechanistic pathways that explain such association.

نویسندگان

Hassan Vatanparast

MD, PhD, Professor, University of Saskatchewan, Canada