THE EFFECTS OF SUPPLEMENTATION WITH PROBIOTIC ON ANTI-OXIDATIVE PARAMETERS IN ADULT SUBJECTS: A SYSTEMATIC REVIEW AND META-ANALYSIS OF RANDOMIZED TRIALS

Background and Aim: Previous studies have supposed that probiotic supplementation led to a positive effect on different health outcomes. Furthermore, several studies indicated probiotics supplementation improved antioxidant status, while some studies did not indicate these effects. Hence, current systematic review and meta-analysis study was conducted to determine the effect of probiotic supplementation on some antioxidant biomarkers among adult subjects.Methods: We searched three electronic databases PubMed-Medline, Scopus, and the Cochrane till November 2017. Clinical trials comparing probiotic supplementation with the control group were included. A random effect model was used to pool Weighted Mean Difference (WMD).Results: Finding of 11 included studies indicated that probiotic supplementation increased total antioxidant capacity (TAC) (WMD: 77.30 mmol/L; 95% confidence interval [CI]: 2.60, 152.01; I2 = 88.3%) and reduced malondialdehyde (MDA) (WMD: -0.31 µmol/L; 95% CI:-0.54, -0.08; I2= 71.5%) significantly compared to the control group. However, its effects on glutathione (GSH) was not significant (WMD = 19.32 µmol/L; 95%CI,-18.70, 57.33; I2= 64.9%).Conclusion: The current meta-analysis revealed that probiotic supplementation may result in increasing TAC and lowering MDA, which improve antioxidant status. Further investigations are required to elucidate the effect of supplementation with probiotics on biomarkers of antioxidants.

کلیدواژه ها:

Supplementation ، Probiotic ، Total antioxidant capacity ، Malondialdehyde ، Glutathione