THE RELATIONSHIP BETWEEN CONSUMPTION OF PHYTOCHEMICALS AND NON-ALCOHOLIC FATTY LIVER DISEASE

Background and Aim: Non-alcoholic fatty liver disease with the prevalence of 25-30% worldwide is the most common cause of chronic liver diseases. Phytochemicals are a heterogeneous group of plant-derived compounds that are introduced as health promoting factors through prevention and treatment of oxidative stress and inflammation. The purpose of this study is to investigate the relationship between the use of phytochemicals and the risk of non-alcoholic fatty liver disease.Methods: The case group (n = 169) was selected from non-alcoholic fatty liver patients who were diagnosed for liver steatosis during the last month by ultrasonography. The control group, 782 subjects whose liver ultrasonography did not show steatosis, were matched with the case group by sex and age. Dietary intake of the year was evaluated by a reliable semi-quantitative food frequency questionnaire. Daily consumption amounts was calculated using the NUTRITIONIST V software.Results: : In people who received the high tertile of phytochemicals consumption, the risk of non-alcoholic fatty liver disease was reduced by 41% compared to those who were in low tertile of consumption, but this effect after adjustment for BMI, smoking and energy consumption was not significantConclusion: Phytochemicals, especially flavonoids can affect the pathogenesis of liver disease. Further studies, especially clinical trials using a standard combination of phytochemical compounds on non-alcoholic fatty liver patients is needed

کلیدواژه ها:

Polyphenol ، Diet ، Non-alcoholic fatty liver disease ، Phytochemical