THE RELATIONSHIP BETWEEN ANTIOXIDANTS AND INFLAMMATION IN CHILDREN WITH ADHD

سال انتشار: 1397
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 380

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شناسه ملی سند علمی:

INC15_427

تاریخ نمایه سازی: 30 دی 1397

چکیده مقاله:

Background and Aim: Recent studies have identified ADHD as an inflammatory condition with immunological and oxidative responses. Therefore, it is necessary to examine these factors in patients. The present study aimed at investigating the relationship between the dietary intake of antioxidants, SOD activity and the serum levels of inflammatory factors in ADHD students.Methods: This study was a retrospective case-control study with 64 ADHD children aged 6 to 13 years. The demographic questionnaire, FFQ, and Baecke physical activity questionnaire were used. SOD activity and the serum level of inflammatory factors (homocysteine, IL-6, and CRP) were measured in all patients. Based on the values obtained from CRP, 32 patients were included in the case group (CRP≥1 mg/L) and 32 in the control group (0≤CRP<1 mg/L).Results: There was no significant difference between the two groups as regards age, sex, weight, height, body mass index (BMI). In the case group, the mean SOD activity score (P=0.034), the physical activity score (P=0.04) and the zinc intake (P=0.02) and homocysteine levels were higher than they were in the control group (P=0.001). Among the variables in the presence of each other, the best predictors were homocysteine (OR:1.34, 95% CI:1.082-1.670, P=0.029) and physical activity (OR:0.85, 95% CI:0.761-0.952, P=0.022) respectively, and in the presence of these two variables, other variables were not significant predictors.Conclusion: The present study showed that the level of inflammatory factors in the case group was significantly higher than the control group. Homocysteine and physical activity can predict the inflammation status induced by CRP.

کلیدواژه ها:

Antioxidants ، Inflammation ، Attention Deficit Disorder with Hyperactivity ، Child

نویسندگان

Iman Namjoo

Department of Community Nutrition, School of Nutrition and Food Sciences, Isfahan University of Medical Sciences, Isfahan, Iran

Amirmansour Alavi Naeini

Department of Community Nutrition, School of Nutrition and Food Sciences, Isfahan University of Medical Sciences, Isfahan, Iran

Mostafa Najafi

Department of Community Nutrition, School of Nutrition and Food Sciences, Isfahan University of Medical Sciences, Isfahan, Iran.

Mohammad Reza Aghaye Ghazvini

Department of Psychiatry, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran