EFFECT OF L-CITRULLINE SUPPLEMENTATION ON BLOOD PRESSURE: A SYSTEMATIC REVIEW AND META-ANALYSIS OF CLINICAL TRIALS

Background and Aim: Several interventional studies assessed the impact of dietary supplements on blood pressure. The aim of the present systematic review and meta-analysis was to determine the efficacy of L-citrulline supplementation on blood pressureMethods: Pubmed, Scopus, Google Scholar and ISI Web of Science were comprehensively searched until May 2018 to assess whether L-citrulline reduces blood pressure. Human clinical trials which reported the effect of L-citrulline supplementation on aortic and brachial blood pressure were included. Characteristics of studies and potential sources of heterogeneity were tabulated. A subgroup analysis was performed to attenuate observed inter-study heterogeneity. Results: A total of five interventions were found for meta-analysis. The impact of L-citrulline on brachial systolic (Change: 0.28 mmHg; 95% CI: -2.87, 2.31 mmHg) and diastolic (Change: -1.56 mmHg; 95% CI: -4.32, 1.20 mmHg) blood pressure was not significant. Also, there was no changes in aortic systolic (Change: 0.22 mmHg; 95% CI: -4.81, 4.38 mmHg) and diastolic (Change: 0.26 mmHg; 95% CI: -2.27, 2.80 mmHg) blood pressure after L-citrulline supplementation. Participants body weight status was a source of observed heterogeneityConclusion: The present systematic review and meta-analysis suggests that L-citrulline supplementation had no beneficial effect on blood pressure

کلیدواژه ها:

L-citrulline ، Blood pressure ، Systematic review ، Meta-analysis