EFFECT OF LACTOBACILLUS CASEI ON WEIGHT MANAGEMENT AND GLYCEMIC CONTROL IN PATIENTS WITH TYPE 2 DIABETES

Background and Aim: To evaluate the effect of Lactobacillus casei 01 (L. casei 01) on dietary intake, body weight, and glycemic control in patients with T2DM Methods: Forty patients with T2DM (n=20 for each group) were assigned into two groups in present trial. The patients in the probiotic group received a daily capsule containing a minimum of 108 CFU of L. casei 01 and the placebo group took capsules filled with maltodextrin for 8 weeks. Dietary intake questionnaires, anthropometric measurements, and blood samples were collected, and the participants were assessed by an endocrinologist at baseline and at the end of the trial.Results: L. casei 01 supplementation significantly decreased total energy, carbohydrate, fat, and protein intake compared with placebo (p = 0.001, p = 0.002, p = 0.009, p = 0.001; respectively). Moreover weight, BMI, and waist circumference were significantly decreased in intervention group compared with placebo group (p < 0.001; p < 0.001; p = 0.029; respectively). The within group changes were significant too (p < 0.05). In comparison with placebo group fasting blood sugar, insulin concentration, and insulin resistance were significantly decreased (p = 0.013, p = 0.028; p = 0.007; respectively) in intervention group. The within group changes were significant too (p < 0.05).Conclusion: The physiologic functions of L. casei 01 could affect food intake and body weight and composition through gastrointestinal pathways and modulation of the gut bacterial community. L. casei 01 supplementation affected Dietary intake and body weight in a way that improved glycemic response in subjects with T2DM.

کلیدواژه ها:

Lactobacillus casei ، Type2 diabetes mellitus ، dietary intake ، body weight ، glycemic control