EFFECT OF VITAMIN E SUPPLEMENTATION ON BLOOD PRESSURE: A SYSTEMATIC REVIEW AND META-ANALYSIS

Background and Aim: Although emerging evidence suggests that vitamin E may contribute to blood pressure improvement, the effects of vitamin E on systolic blood pressure (sBP), diastolic blood pressure (dBP) and mean arterial pressure (MAP) are still controversial. The aim was to evaluate the influence of vitamin E on sBP, dBP and MAP through meta-analysisMethods: We identified all studies that assessed the effect of vitamin E supplementation on sBP, dBP and MAP from PubMed/Medline, SCOPUS and Google scholar up to March 2018. Weighted mean differences (WMD) and 95% confidence interval (CI) were expressed as effect size. Pre specified subgroup was conducted to evaluate potential heterogeneity. Meta-regression analyses were performed to investigate association between blood pressure-lowering effects of vitamin E and duration of follow-up and dose of treatmentResults: Eighteen trials, comprising 839 participants met the eligibility criteria. Results of this study showed that compared to placebo, sBP decreased significantly in vitamin E group (WMD= -3.4 mmHg, 95%CI= -6.7 to - 0.11, P<0.001), with a high heterogeneity across the studies (I2= 94.0%, P<0.001). Overall, there were no significant effects on dBP and MAPConclusion: This meta-analysis suggested that vitamin E supplements decreased only sBP and had no favorable effect on dBP and MAP

کلیدواژه ها:

vitamin E ، blood pressure ، hypertension ، mean arterial pressure ، meta-analysis