ASSOCIATION OF DIETARY INFLAMMATORY POTENTIAL WITH CARDIOMETABOLIC RISK FACTORS AND DISEASES: A COMPREHENSIVE SYSTEMATIC REVIEW AND META-ANALYSIS OF OBSERVATIONAL STUDIES

Background and Aim: The association between dietary inflammatory index (DII®), an index developed to assess the inflammatory quality of diet, and cardio-metabolic risk factors and cardiometabolic diseases from observational studies has been inconsistent. Therefore, the current systematic review and meta-analysis study was performed to investigate the association between DII and cardiometabolic risk factors and cardiometabolic diseases. Methods: Published observational studies with the aim of examining the association between DII and cardiometabolic risk factors and cardiometabolic diseases using PubMed, Scopus, ISI Web of Science, and Google Scholar databases were searched from inception through October 2017. Proper keywords were applied to the comprehensive search.Results: Meta-analyses of published observational studies demonstrated no association between DII and metabolic syndrome (MetS) (OR: 1.02; 95% CI: 0.86-1.18) and its components. Increased DII (when used as a continues variable) was associated with higher risk of morbidity (HR=1.06; 95% CI: 1.03-1.09) and mortality (HR=1.06; 95% CI: 1.03-1.08) from cardio-metabolic diseases. Moreover, most pro-inflammatory diet (the highest DII category) versus most anti-inflammatory diet (the lowest DII category) was associated with greater risk of morbidity (HR=1.31; CI: 1.12-1.49) and mortality (HR=1.13; 95% CI: 1.05-1.21) of cardiometabolic diseases. Conclusion: Adherence to pro-inflammatory diet was not accompanied with increased MetS, whereas it was associated with elevated morbidity and mortality due to cardiometabolic diseases.

کلیدواژه ها:

Diet ، Inflammation ، Cardiovascular diseases