INCREASED SERUM S100A1, ZAG AND ADIPONECTIN IN CACHECTIC PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE ARE NOT ASSOCIATED WITH ALTERATIONS OF RESTING METABOLIC RATE

Background and Aim: Chronic obstructive pulmonary disease (COPD) is an irreversible obstructive airway disease. S100A1, ZAG and adiponectin are important regulators of energy metabolism and body weight. Therefore, the aim of this study was to assess resting metabolic rate (RMR) and its association with serum levels of S100A1, ZAG and adiponectin in cachectic and non-cachectic COPD patients.Methods: Ninety men with COPD and age range of 40-70 years were enrolled in the study. Patients were divided into two groups of non-cachectic (n= 45) and cachectic (n= 45) according to unintentional weight loss> 7.5% in previous 6 months. The groups were matched based on age and BMI. RMR was measured by indirect calorimetry method. Anthropometric indices and body composition were also measured. Serum levels of S100A1, ZAG and adiponectin were assessed by ELISA. Results: Cachectic patients had significantly higher RMR than controls (P< 0.001). Serum levels of ZAG, S100A1 and adiponectin were significantly higher in the cachexia group (P< 0.0001). RMR were not significantly associated with S100A1, ZAG and adiponectin levels. However, weight loss of patients was significantly associated with serum levels of ZAG and adiponectin (both, β= 0.22, P= 0.03). Strong association was found between the serum levels of S100A1 and ZAG (β= 0.88, P< 0.0001), S100A1 and adiponectin (β= 0.86, P < 0.0001) and also ZAG and adiponectin (β= -0.83, P< 0.0001).Conclusion: The potential role of these factors in the wasting process is considerable. Also, the association between serum levels of S100A1, ZAG and adiponectin represents that these three proteins are probably related to specific functions.

کلیدواژه ها:

COPD ، Cachexia ، RMR ، S100A1 ، ZAG ، Adiponectin