The use of water as a solvent for organic transformations offers several green chemistry
benefits Water is the lingua franca of life on our planet and solvent of choice for nature to carry out her synthese. The products of passerini reactions are common organic building blocks for natural products and drugs. Also the passerini reaction is interesting because it is having 100% atom-economy. This means that every atom in the starting materials is incorporated in the product . Recently several papers on the synthesis of variety of novel compounds have been published using one-pot three-component
approaches. Following Preliminary experiments demonstrating that passerini reaction are significantly accelerated on water
and in connection with our recent interest in benign synthetic protocols . we became interested in developing versatile and efficient one-pot synthesis of 2-(cyclohexyl amino) -2-oxo-1-phenylethyl 2-((2,3-dimethylphenyl) amino) benzoate derivatives using Mefenamic acid, aldehydes and cyclohexyl isocyanid (scheme 1) .in this study several aldehydes were examined. This rapid method produced the products in short reaction tines (40-45 min) and excellent yields (90-95%). the structures of the products were assumed from their elemental analyses and spectroscopic data.