Neutrophil lymphocyte ratio (NLR) and the extent of coronary artery stenosis in patients with non ST elevated-acute coronary syndrome (NSTE-ACS)

Introduction: Cardiovascular diseases are the leading cause of mortality in Iran and in the world. Considering the importance of inflammation in atherosclerosis, evaluating inflammatory factors and their contribution to cardiovascular diseases is essential. Accordingly, this study evaluates the link between neutrophil lymphocyte ratio (NLR) and coronary artery stenosis in patients undergoing coronary angiography.Materials and Method: This study was performed on 372 patients who underwent coronary angiography for NSTE-ACS. In addition to demographics, NLR and the extent of coronary artery disease were measured in patients. Chi-Square and ANOVA tests were used to compare the data.Results: Our study showed a direct and significant correlation between neutrophil lymphocyte ratio and the extent of coronary artery disease (CAD) (r = 0.125 and P = 0.016). Also, by examining the diagnostic accuracy of the neutrophil lymphocyte ratio in CAD, it was found that the best cut point was 2.4 (the area under the ROC curve was 0.69), with sensitivity of 72.4% and specificity of 58.3%.Conclusion: Neutrophil lymphocyte ratio is directly and significantly correlated to the extent of involvement of coronary arteries in patients with NSTE-ACS, and it can be used to predict the involvement and extent of CAD.

کلیدواژه ها:

neutrophil ، lymphocyte ratio ، Coronary Artery Angiography ، Extent of involvement