Effects of Turmeric Supplementation on Serum Lipid Profile and Blood Pressure in Patients with Nonalcoholic Fatty Liver Disease

Introduction: Nonalcoholic fatty liver disease (NAFLD) is considered as an independent risk factor for cardiovascular disease (CVD).Dyslipidemia and hypertension contribute to the enhanced risk of CVD in persons with NAFLD. This study aimed to investigate the effects of turmeric supplementation on serum lipids levels and blood pressure (BP) in patients with NAFLD.Methods: In this double-blind, randomized, controlled clinical trial, 46 NAFLD patients (21 males and 25 females; age range, 20 – 60 years) were randomly assigned in the two groups. The intervention and control groups received 3g of turmeric (n = 23) and placebo (n = 23), daily for 12 weeks. Fasting blood samples and BP measurements were collected at baseline and at the end of the trial.Results: Turmeric supplementation significantly increased serum levels of HDL-C compared with the placebo group at the end of the study (by 12.73%, P <0.05). Serum levels of TG, TC and LDL-C were significantly reduced within turmeric group at the end of study (P<0.05). Systolic blood pressure (SBP) improved in turmeric group compared to its baseline values. Diastolic blood pressure did not change significantly in any of groups.Conclusion: Turmeric consumption had beneficial effects on serum lipids levels and SBP of subjects and maybe useful in controlling of CVD risk factors in NAFLD patients.

کلیدواژه ها:

Turmeric ، Serum lipids ، Blood pressure ، Nonalcoholic Fatty Liver