Improving the quality of aspirin tablets in the treatment of thromboembolic diseases

Introduction: Aspirin low dose blocks an enzyme called cyclooxygenase in the platelets and inhibits platelet aggregation in this way. Aspirin tablet is used in thromboembolic disorders, transient ischemic attacks, and reduction of the risk of heart attack in patients with a history of myocardial infarction and unstable angina. Acetylsalicylic acid, also known as aspirin, is an analgesic-antipyretic medicine made by salicylic acid interacting with acetic anhydride. It will be slowly hydrolyzed to salicylic acid and acetic acid in moist air, and aqueous solution has acidic reaction.Hydrolysis of the drug can be a major reason for the instability of drugs. Thus, when Aspirin undergoes hydrolysis (It absorbs moisture from the atmosphere easily), the degradation products are salicylic acid (as impurity) and acetic acid.Below studies was performed to find out which combination of excipients in tablet core, which packaging system, which coating system, and which stability condition (Accelerated or intermediated) would be suitable for use in an aqueous enteric film coating aspirin tablets.Results: A formulation of microcrystalline cellulose (MCC) and partially pregelatinized starch (P-PGS) without any disintegrant was found to provide the necessary properties. In the formulation, MCC provides the compatibility needed to produce a table. P-PGS provides the dissolution characteristics and is responsible for the stability characteristics. Parameters effective on one year stability, Is the goal of the present study. Bioequivalence studies show the satisfactory drug effects

کلیدواژه ها:

Aspirin ، humidity ، stability ، packaging ، coating