Montelukast for medical delay in flap surgery

Background: Delay phenomenon can be used for better blood supply of the flap in plastic surgery. Effects of montelukast have been observed to reduce ischemia/reperfusion injuryin various organs due to angiogenic properties and anti-oxidant effects. The present study aimed to to det ermine the role of montelukast as medical delay of the flaps.Methods: In this experimental study, 42 Wistar rats were divided into three equal groups. These groups were Surgical Delay Group (SDG), Medical Delay Group (MDG) andControl Group (CG). In SDG, 8*3 cm rectangular randomized random skin flap was first surgically delayed at rats’ back. The MDG received oral montelukast 10 mg/kg viaorogastric tube for 5 days as medical delay. In MDG and SDG flap harvest was done after a delayed period but there was no any delayed period in CG. Finally, in all groups a 8*3cm rectangular random skin flap was harvested at the back of the rats and a 3*3 mm skin segment of the most distal part of the viable skin flap was biopsied for assessingangiogenesis then flap was returned to its original site. After the 14th day, the photos were taken and size of the necrotic area of the flap was measured by using image-j program.Results: Based on the results, a significant difference was observed between the mean survival and angiogenesis (P=0.002). The same performance was reported between MDGand SDG which were alike regarding survival and angiogenesis (P > 0.05) while there was a significant difference between control and surgical groups, as well as control and medical groups (P < 0.05). Finally, the inflammation showed no significant difference (P > 0.05).Conclusion: Regarding positive effects of Montelukast on survival and angiogenesis, it isrecommended to use this medication for larger study.

کلیدواژه ها:

Flaps ، Medical Delay ، Montelukast