Corellation of tumor angiogensis with tumor stage in colonic adenocarcinoma with CD 34 immunohistochemical staining in Kerman between 1389 to 1393

سال انتشار: 1397
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 398

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شناسه ملی سند علمی:

AFZMED02_010

تاریخ نمایه سازی: 30 دی 1397

چکیده مقاله:

Introduction: The aim of this study was to investigate the association of tumor angiogenesis with tumor stage in adenocarcinoma of colon with specific coloring of CD34in Kerman between 1393 and 1395. Materials and Methods: In this study, the blocks of patients diagnosed with adenocarcinoma of the colon were collected from AfzalipourHospital in Kerman between 1393 and 1395, along with patient information (age of locus of lesion site). We classified the angiogenesis (luminal vessels without muscle wall) with specific coloring of the CD34 and divided into three groups: mild, moderate and severe, based on the number of vessels in the four fields of the microscope. Eventually, the average number of vessels per lam was considered as the average of the small vessels in the tumor and was reported on the basis of the mentioned groups. Results: A total of 60 patients were enrolled in the study, most of whom were males. The mean age in the subjects was 59.1 ± 13.3 years old. In the data Proximal cecum was also the most common site of the tumor, and most of the tumors were mesenous bread with a moderate and moderate differentiation of tissue lymphocyte infiltration. The mean number of vessels in an HPF specimen was 25.2 ± 8.9 which had the highest vein in this poster, and the lowest was 11. In this category, in the HPF view, we described less than 15 mild vessels, between 15 and 30 modreets, and more than 30 vessels that were severe, of which 12 patients (20%) were in the mild category, 29 (48.3%) in the category Moderate and 19 patients (31.7%) were in severe category Conclusion: In the analysis of data on the number of vessels and the staging of the tumor, it has been shown that the number of vessels in the lower stages of the disease issignificantly lower. It was also shown that in patients with more distinctly cellular differentiation, there was a significant increase in the number of vessels, but there was nosignificant difference between the number of vessels with gender, age, lymphocytic infiltration, tumor location and type of tumor.

نویسندگان

Maryam Iranpour

Department of Pathology, Pathology and Stem Cell Research Center, Kerman University of Medical Sciences, Kerman, Iran

Jahanbanoo Shahryari

Department of Pathology, Pathology and Stem Cell Research Center, Kerman University of Medical Sciences, Kerman, Iran

Mohamad Karim Aghaei

Physiology Research Center, Kerman University of Medical Sciences, Kerman, Iran