Bacterial agents and their antibiotic resistance in neonatal septicemia

Background: Neonatal septicemia is one of the most important neonatal diseases that are associated with high morbidity and mortality. Knowledge about the cause and bacteriological characteristics of septicemia are important and contributing factor for reduction of neonatal death. Therefore, the present study was conducted to investigate bacterial agents and antibiotic resistance in neonatal septicemia. Methods: In this review article, the comprehensive search was conducted in PubMed, Scopus, Science Direct, Ovid, Web of Science, SID and Magiran, with using septicemia, bacterial agents, neonatal diseases and antibiotic resistance keywords. Of the articles that have been published since 2010 to 2016, 23 articles were selected and studied. Results: According to studies, %61.7 of the bacteria was gram-positive and %38.3 was gram-negative. Among gram-positive bacteria, Staphylococcus aureus (%31.1) and among gram-negative bacteria, Klebsiella pneumoniae (%16.7), were the most common isolated bacteria. The most sensitive antibiotics in isolated bacteria were Ciprofloxacin (%74.63), Imipenem (%34.37) and Co-trimoxazole (%48.63). The highest resistance in gram-negative bacteria was related to Ceftriaxone (%71.6), Gentamicin (%69.3) and Cefotaxime (%63.7); and in gram-positive bacteria was related to Co-trimoxazole (%35.3), Gentamicin (%32.4) and Ceftriaxone (%29.4). Conclusion: Ciprofloxacin and imipenem antibiotics seem to be the proper drugs to start treatment before the antibiogram is preparing.

کلیدواژه ها:

Septicemia ، Bacterial agents ، Neonatal diseases ، Antibiotic resistance