Effect of mucoadhesive nigella sativa in the treatment of chronic periodontitis

Background and Objective: The goal of this study was to compare the clinical effectiveness of mucoadhesive Nigella sativa extract with mucoadhesive thymoquinone as an adjunct topical treatment accompanied by scaling and root planning; as well as comparing them with the outcomes from scaling and root planning alone in treating chronic periodontitis. Material and method: This study was a randomized-triple blinded clinical trial and was conducted on 20 patients suffering from chronic periodontitis. Immediately after the scaling and root planning for all regions, first sextant was applied with placebo, second one was applied with mucoadhesive nigella sativa extract gel, third mucoadhesive thymoquinone gel and last one has no adjunct treatment. Investigated indexes including gingival index, bleeding index, plaque index, pocket depth, and clinical attachment loss were assessed before and in one week, two weeks, one month and three months after treatment. Findings: The findings from this study supported the effectiveness of both mucoadhesive nigella sativa and mucoadhesive thymoquinone, in company with scaling and root planning, in improving gingival index, bleeding index, plaque index, pocket depth, and clinical attachment loss in all of the time periods under investigation; Bleeding index and plaque index has not significant different in long term In none of the groups. In the end of the study nigella sativa group (NS) with 1.7 degree reduction in gingival index and it was fewest measure (P˂0.004) but it has not significant different in compare with thymoquinone group (TQ) with 1.3 degree reduction. About pocket depth NS with 2.25mm reduction has fewest measure (P˂0.001) but it has not significant different in compare with thymoquinone group with 1.45mm reduction. About clinical attachment loss NS with 1.38mm reduction has fewest measure (P˂0.001) but it has not significant different in compare with thymoquinone group with 0.87mm reduction. Moreover, findings of this study indicated that time can affect the effectiveness of each of the variants of this study. Conclusion: The findings from this study indicated that the use of adjunct treatment to mechanical debridement is more effective in treatment of chronic periodontits compared to mechanical treatment alone; furthermore, mucoadhesive nigella sativa and mucoadhesive thymoquinone have not significant different in long-term and the main treatment effect of nigella sativa is because of its thymoquinone probably.

کلیدواژه ها:

chronic periodontitis ، mucoadhesive ، nigella sativa ، thymoquinone