Reno–Protective Effects of VitaminB12 on Aminoglycosides induced nephrotoxicity in rat

سال انتشار: 1397
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 560

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شناسه ملی سند علمی:

AMSMED19_123

تاریخ نمایه سازی: 1 دی 1397

چکیده مقاله:

Background and Objective: Aminoglycosides are one of the common causes of drug-induced nephrotoxicity. The antioxidant, anti-inflammatory effect of Vitamin B12 was investigated on gentamicin nephrotoxicity in rats. Materials and Methods: Renal injury induced by i.p.injection of gentamicin (100 mg/kg) for 8 consecutive days. (6 mg/kg/day, i.p) treatment was done for 8 consecutive days as co-treatment and post-treatment protocol. Findings: Vitamin B12 significantly compensated deficits in the antioxidant defense mechanisms, suppressed lipid per oxidation and ameliorated renal tissue damage mediated by gentamicin. Conclusion: The results of the current study indicated VitaminB12 that effectively protected the kidney tissue against gentamicin induced acute nephrotoxicity in rats and increased anti-inflammatory defense.

نویسندگان

Zeinab Hamidizad

Arak University of Medical Sciences, Arak, Iran.

Saeed Hajihashemi

Arak University of Medical Sciences, Arak, Iran.

Ali Rahbari

Arak University of Medical Sciences, Arak, Iran.

Leila Ghanbari

Arak University of Medical Sciences, Arak, Iran.