Preparation of Biocompatible Oral Adhesives Based on Polyurethane

Tissue adhesives are changing continuously due to technology and innovations. Tissue adhesives have been considered in the field of jaw and facial surgery. In these surgeries, the closure of soft tissue ulcers is done with primary and mechanical methods such as sutures and staplers. The major problems with the use of mechanical methods have led surgeons to think about ways to replace them. In the meantime, tissue adhesive has been used extensively for its good advantages, including the insulator bleeding, ease of use, and reduced surgical time. However, available tissue adhesives still have many limitations, including high cost, low adhesion strength, exhausting preparation, the possibility of transmission of infection and high toxicity. The aim of this project is to provide biocompatible oral adhesive based on polyurethane to overcome some of the problems caused by the lack of optimum material. In this study, the synthesis of adhesive was carried out in two steps. In the first step, polyurethane pre-polymer was synthesized. The presence and quantity of NCO groups were investigated using FTIR technique, and the poly urethane group and free NCO bands in the adhesive were detected as 2257 cm-1 and 1515 cm-1 respectively. The molecular weight of the base polymer was determined 4142 g / mol using GPC technique. In the second step, in order to improve adhesive properties, 2% of the chitosan gel and 0.1% carboxymethyl cellulose were added to the adhesive composition. Then adhesion of the cells to the structure of the synthesized adhesive was observed with SEM technique, the survival rate of the samples by MTT colorimetric method on the L929 fibroblast cell line according to ISO 10993-05 was obtained. which seems to be a good fit in comparison with the adhesion of the base polymer and fibrin Glubran 2 adhesive. At the end, it seems that the polyurethane-based oral adhesive is competitive with other tissue adhesives in terms of adhesion and provides acceptable results in terms o f biocompatibility.

کلیدواژه ها:

Tissue Adhesive ، Oral Adhesive ، Polyurethane ، Chitosan gel ، Carboxymethyl Cellulose ، Biocompatiblity