Synthesis of N-2-(2-furyl)-2-(chlorobenzyloxyimino) ethyl norfloxacin derivatives

As part of a continuing search for new potential anticancer candidates in the piperazinyl quinolone series, the cytotoxicity evaluation of new Nsubstituted piperazinyl quinolones was of our interest. The growth inhibitory activities of new compounds, namely N-[2-(furyl-2-yl)-2-chlorobenzyloxyiminoethyl] piperazinyl quinolones 1-3 were determined against cancer cell line using MTT colorimetric assay. Preliminary screening showed that one of the new N-[2-(furyl-2-yl)-2-chlorobenzyloxyiminoethyl] piperazinyl quinolones 3 containing (un)substituted oxime moiety showed significant cytotoxic activity. Thus, in the piperazinyl quinolone series,cytotoxic activity can be positively modulated through the introduction of 2-(furyl-2-yl) ethyl residue on the piperazine ring. The results revealed that the introduction of 2-(2-furyl-2-yl)ethyl moiety on the piperazine ring of quinolone antibacterials (norfloxacin) changes the biological profile of piperazinyl quinolones from antibacterials to cytotoxic agents.

کلیدواژه ها:

cytotoxic ، norfloxacin ، 2-furyl