Fabrication and Characterization of Hydroxyapatite Nanoparticles with High Biomedical Performance

Mechanochemical process in polymeric and metallic vials has been carried out successfully to produce hydroxyapatite (HAp) nanoparticles. Morphological properties and structural evaluation of obtained materials are studied by X-ray diffraction (XRD) and transmission electron microscopy (TEM). The obtained data show that the increase in milling time leads the increasing in lattice strain and decreasing in crystallite size. Based on XRD patterns and TEM micrographs, the possible formation mechanism of hydroxyapatite nanoparticles by mechanochemical process in polymeric milling media is confirmed. Final results indicate that the hydroxyapatite nanoparticles with low chemically stable contaminations and spherical morphology can be produced in Polymeric vials similar to stainless steel vials. Since spherical geometry is preferable for avoiding inflammation and achieving osteointegration, compared to irregular shape, obtained product is preferred for medical applications.

کلیدواژه ها:

Lattice Strain ، Nanoparticle ، Hydroxyapatite ، Polyamide 6