The effect of hyperlipidemia patterns on complete blood cell count: a case control study

Objective: Despite the speed and accuracy of cell counting devices in the analysis of blood samples, several confounding factors may influence their outcomes. This studywas performed to assess the effect of hyperlipidemia patterns on the results of complete blood cell count (CBC). Methods: This analytical study (case-control) was performed on 306 non-diabetic and non-anemic patients which were divided into 5 groups: 1)Cholesterol above 200 mg/dl, 2) Cholesterol above 200 mg/dl and LDL over 130 mg/dl, 3) Cholesterol 200 mg/dl and normal LDL , 4) Triglycerides above 150 mg/dl, 5)Cholesterol above 200 mg/dl and triglycerides above 150 mg/dl. The blood cell count and indices were compared with the control group. After obtaining samples from participants, the level of blood lipids and complete blood cell count were measured. Finally, Statisticalanalysis and comparison between two groups were performed with SPSS software. Results: Comparison between case and control groups separately in each of the five groups showed the following results: 1) the WBC and PLT in the group with high cholesterol levels were significantly higher than the control group (p <0.05). 2) the WBC and PLT in the group with high cholesterol and LDL were significantly higher than the control group (p <0.05). 3) The WBC in the group with high cholesterol and normal LDL was significantly higher than the control group (p <0.05). 4) The RBC, MCV and MCHC in the group with high triglycerides were significantly higher than the control group (p <0.05). 5) The RBC, WBC and PLT in patients with high cholesterol and triglyceride levels were higher than the control group (p <0.05). Conclusion: Our study showed that hyperlipidemia patterns clearly increased blood cell count and indices.Therefore, hyperlipidemia patterns should be considered as a confounding factor in the interpretation of complete blood cell count.

کلیدواژه ها:

Hyperlipidemia ، Cholesterol ، LDL ، Triglycerides ، Complete Blood cell Count ، Blood Indices