Evaluation of biochemical and immunological changes in patients with rheumatoid arthritis

Background: Rheumatoid arthritis (RA) is a chronic inflammatory disease that mainly involves the joints of the body. The disease affects approximately one percent of the world population. several reasons for rheumatoid arthritis has been introduced. Rheumatoid arthritis patients compared with healthy people experience a series of biochemical and immunological factor changes in the diagnostic criteria of the disease. The aim of this study was to determine the basic characteristics of the modified RA patients and compare them with healthy individuals. Search method: The study was conducted by searching the English and Persian databases like: Pubmed, ovid, Google scholar, Cochrane, SID, Magiran and Iranmedex. The main keywords used included rheumatoid arthritis, rheumatoid factor and Anticcp. We used original and review articles that published in 1988 till 2015. Among 65 related articles, 35 articles with the full text access were reviewed. Findings: According to result obtain, patients with RA have a high level of rheumatoid factor (RF). The specificity of RF in RA patients is about 70-90%. this may be a factor in healthy and positive in other diseases is not very specific. The anti cyclic-citrullinated peptide (Anticcp) antibodies is a more specific marker for RA with a higher specificity. Also there are anti-nuclear antibodies (ANA) which can be positive. In these patients, inflammatory factors such as interleukin-6 promoter is increased and consequently the acute phase proteins such as CRP increases. The researches have shown that the risk for women three times more than men, probably due to high levels of estrogen in women. In other studies, elevated levels of copper and reducing the amount of zinc and selenium in patients with rheumatoid arthritis have been observed. In addition, increasing the amount of uric acid, reducing the amount of magnesium and dyslipidemia were seen and was associated with increased risk of cardiovascular diseases. Also, oxidative stress is produced in these patients. probably due to lack of performance or lack of antioxidant enzymes.Conclusion: Since rheumatoid arthritis is a debilitating disease and can increase the risk of cardiovascular diseases and osteoporosis, it should be identified quickly, so that serious complications could be prevented or at least delayed .

کلیدواژه ها:

rheumatoid artiritis ، rheumatoid factor and anticcp