Clinical significance of putative cancer stem cell markers CD44 and CD133 in prostate carcinomas
محل انتشار: هفدهمین همایش سالانه آسیب شناسی و طب آزمایشگاه
سال انتشار: 1394
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 433
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شناسه ملی سند علمی:
ACPLMED17_052
تاریخ نمایه سازی: 20 آبان 1397
چکیده مقاله:
Introduction: Based on valuable role of putative cancer stem cell markers CD44 and CD133 to identify the potential prostate CSCs and controversial expression level of putative cancer stem cell markers CD44 and CD133 in prostate tumors, current study was conducted to evaluate the co-expression level and clinical correlation of these markers in a series of Iranian prostate tissues. Method: 155 prostate tissues composed of prostate cancer (PCa), high-grade prostatic intraepithelial neoplasia (HGPIN), and benign prostate hyperplasia (BPH) which were included in Tissue microarray (TMA) have been immunohistochemicaly examined for the expression of CD44 and CD133. The correlation of both CSC markers expression with clinicopathological parameters was also assessed. Results: The positive expression of CD44 and CD133 was observed in 60.3% and 46.2% of PCa specimens, respectively. The higher level of CD44 expression was more often seen in PCa cases with low Gleason score and TNM stage (P = 0.025 and P= 0.086), while there was no significant correlation between CD133 expression and clinicopathological parameters. In parallel, the co-expression of CD44 and CD133 (CD44+/CD133+ phenotype) was significantly displayed in PCa cases with low to moderate Gleason score (P=0.046). Conclusion: These findings suggest that Immunohistochemical analysis of CD44 and CD133 expression was in parallel with combined analysis, which demonstrated that CD133 may not be a suitable cancer stem cell marker in PCa, while its co expression with CD44 could be correlated with Gleason score of PCas
کلیدواژه ها:
نویسندگان
Elham Kalantari
Oncopathology Research Center
Mojgan Nikpanah
Oncopathology Research Center, Iran University of Medical Sciences, Tehran, Iran
Naghmeh Salarieh
Oncopathology Research Center, Iran University of Medical Sciences, Tehran, Iran
Mojgan Asgari
Oncopathology Research Center, Iran University of Medical Sciences, Tehran, Iran