Comparison of mast cell concentration in peripheral and central giant cell granuloma:a comparative study

سال انتشار: 1394
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 381

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شناسه ملی سند علمی:

ACPLMED17_045

تاریخ نمایه سازی: 20 آبان 1397

چکیده مقاله:

Introduction:Giant cell granuloma is a lesion with proliferation of giant cells in a mesenchymal stroma. In maxillofacial region this lesion occurs in 2 clinical forms despite histopathological similarity of these 2 forms a totally different clinical behavior is reported for them;as mast cells concentration is higher in some of high aggressive tumors comparing to lower aggressive.On the other hand,according to some studies mast cells have an important role in process of angiogenesis and tumor progression.so,comparing mast cells concentration in these 2 clinical forms of giant cell granuloma may be useful in evaluation of the difference in their clinical behavior. Objective:Aim of the present study is to compare mast cell concentration in CGCG and PGCG.Material and method:In this study 20 pathological samples of CGCG And 20 samples of PGCG were selected and examined.Paraffin blocks consist of CGCG and PGCG lesion with sufficient amount of tissue were selected and collected for toluidine blue staining for mast cell assessment.The counted numbers by 2 observers for all slides as well as all information regarding patient s sex and age in analyzed data were recorded.For comparing number of mast cells in 2 group of central and peripheral giant cell granuloma statistical examination of independent data(T-test) was used.Also for assessment of spontaneous effect of variables such as sex,age and site of the tumor on concentration of mast cells,regression method backward multi variable linear method was used.All statistical operation was done using SPSS20 software and p value of lower than 0.05 were considered significant.difference in mast cell demonstrated that there is a significant This study:Results are between CGCG and PGCG meaning that mast cell concentration concentration to PGCG.Also no relation was exist between age,sex and comparing higher in CGCG concentration of mast cells lesion and site of the in this .PGCG The higher mast cell concentration of CGCG comparing to:Conclusion clinical behavior,but due to widespread may be related to its more aggressive study future studies are suggested to detect specific role of this cell,action of mast cells

کلیدواژه ها:

Central giant cell granuloma ، peripheral giant cell granuloma ، mast cell

نویسندگان

Elahe Komasi

Dentist,Private Practice,Tehran,Iran

Sareh Farhadi

Assistant professor,oral and maxillofacial pathology department,dental branch of tehran ,islamic azad university,tehran

Ferial Taleghani

Assistant Professor,Department of Periodontology,Faculty of Dentistry,Shahed University,Tehran,Iran