Comparison between Selegiline and Acetyl L-Carnitine after spinal cord injury

Aim:The aim of this study was to compare the neuroprotective effect of Selegiline and Acetyl LCarnitine.Materials and Methods:By the use of Aneurysm Clips we injuried spinal cord in adult female rats in means of studySpinal Cord Injury(SCI).Then animals were devided into 3 groups depended on the type oftreatment : 1_treated with Selegiline 2- treated with Acetyl l-Carnitine 3_ Injected normalsaline as control.Injections were continued for 21 days .After this period they were sacricifiedby transcardiac perfusion and spinal cord was prepared for microscopic study .Totalmotoneurons counts were done in anterior horn of spinal cord and motoneurons reductionwere calculated . Apoptosis in these neurons were studied by ultrastructure technique.Results:Motoneurons reduction were decreased in the group which were treated with Acetyl l-Carnitine, and increased in the control group. The ultrastructural study of mitocondria showeschanges known as cromatolysis.Conclusion:Neuroprotective effect of Acetyl L-Carnitine is more than Selegiline and farther more studiesis necessary to recognize this.

کلیدواژه ها:

Selegiline-Acetyl L-Carnitine-SCI