The relationship betweenMDM2 expression and tumor thickness and invasion in primary cutaneous malignant melanoma

سال انتشار: 1391
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 338

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شناسه ملی سند علمی:

ACPLMED14_042

تاریخ نمایه سازی: 20 آبان 1397

چکیده مقاله:

Background: Malignant melanoma is the most invasive cutaneous tumor which is associatedwith an incredibly high mortality rate. The most reliable histological factors associated withmelanoma prognosis are tumor thickness- measured by the Breslow index- and invasiondepth- measured by Clark level. Murine double minute 2 (MDM2) gene inhibits p53-dependent apoptosis. An increase in MDM2 expression has been found in many tumors. Thisstudy aimed to investigate MDM2 expression and its correlation with tumor thickness andinvasion level in malignant melanoma. Materials and Methods: This study evaluated paraffinblocks from 43 ran- domly selected patients with primary cutaneous melanoma who referredto the main university pathology center in Isfahan, Iran. MDM2 expression rate was assessedvia immunohistochemical techniques and hematoxylin and eosin staining to determine tumorthickness and invasion level. Correlations between MDM2 expression and tumor thicknessand invasion were analyzed using Spearman s correlation coefficient in SPSS17. Results: Themean age of patients was 61.2 ± 15 years. Men and women constituted 55.8% and 44.2% ofthe participants, respectively. The rate of MDM2 positivity was 28.9%. MDM2 expressionwas directly associated with tumor thickness (r = 0.425; p = 0.002) and weakly with invasionlevel (r = 0.343; p = 0.01). Conclusions: Despite the low MDM2 expression rate observed inthis study, direct relationships between MDM2 positivity and tumor thickness and invasionlevel were identified. MDM2 expression can thus be suggested as a potential new predictiveprognostic factor.

کلیدواژه ها:

Melanoma ، Murine Double Minute 2 ، Prognosis

نویسندگان

P Rajabi

Department of Pathology, Isfahan university of medical sciences, Isfahan, Iran

M Heidarpour

Department of Pathology, Isfahan university of medical sciences, Isfahan, Iran

P Karimian

Department of Pathology, Isfahan university of medical sciences, Isfahan, Iran