THE EFFECT OF NATIVE IRANIAN PROBIOTIC BACILLUS COAGULANS 6068 AND MEDICAGO SATIVA EXTRACT ON LOWERING BLOOD SUGAR AND HEPATIC ENZYMES ACTIVITY IN DIABETIC RATS

Background and Aim:Diabetes is a chronic disease which is caused by lack of insulin production or the inability of cells in using insulin.There are lots of methods for its treatment although they ll be encountered with many problems, so in this case the importance of integrating new method for treatment and also its prevention are implicated. The aim of this research is using native Iranian probiotic and sativa extract on reducing blood sugar levels in diabetic rats.Methods:. In this study 35 male rats are injected and characterized by Streptozotocin which is utilized for diabetic.They were divided into five groups The: normal control , diabetic control, diabetic receiving probiotics diabetic receiving sativa , group V: diabetic received probiotic and sativa. Bacillus coagulans6068 is employed with concentration of 109 cfu/ml .Probiotic and sativa extract was given daily by gavage to groupsResults:. After 21 days from cardiac puncture blood samples were taken and serum markers including blood sugar, Hepatic Enzymes were analyzed and studied. The results demonstrated significant reduction in blood glucose(61%), sgpt(50%), and sgot (35%)Conclusion:Consumption of probiotic Bacillus coagulanse 6068 with Sativa extract has a significant effect on the control of blood glucose and other liver factors.

کلیدواژه ها:

probiotic(Bacillus coagulans 6068) ، blood glucose ، Hepatic Enzymes ، sativa extract