THE EFFECT OF LACTOBACILLUS PLANTARUM AND HONEY-DERIVED LACTOBACILLUS RHAMNOSUS ON GASTRITIS CAUSED BY HELICOBACTER PYLORI IN C57BL/6 MOUSE MODEL

Background and Aim:Helicobacter pylori is one of the most common pathogenic bacteria in the human gut, which is one of the most important factors in causing digestive disorders such as chronic inflammation, gastric ulcers and even gastric cancer. Since the use of various antibiotics to treat H. pylori infection is associated with development of resistance in this bacterium, therefore, the aim of this study was to determine the antimicrobial effects of Lactobacillus rhamnosus(L. rhamnosus) and Lactobacillus plantarum(L. plantarum) as probiotic compounds on H. pylori induced gastritis in C57BL / 6 mouse model.Methods:Materials and Methods: In this experimental study, the mice were infected 4 weeks after the last infection with standard strain of H. pylori (ATCC 43504). Fourteen days after the last exposure, responses to the treatments and the efficacy of the compounds were evaluated by H. pylori stool antigen test and tissue stainingResults:Based on ELISA results and histological findings, reduction of inflammation was observed after exposing H. pylori infected mice with L. plantarum and L. rhamnosus. So that L. rhamnosus exposure group and exposure group containing all two strains of Lactobacillus showed the highest antimicrobial effect on H. pyloriConclusion:According to the results of this study L. plantarum and L .rhamnosus as a probiotic compound can be beneficial as a pharmaceutical supplementation which can have useful effects in the elimination of bacteria.

کلیدواژه ها:

Helicobacter pylori ، Lactobacillus ، Probiotic ، Gastritis