THE MICROBIOTA OF FEMALE REPRODUCTIVE TRACT AND ITS RELATION TO FERTILITY AND ASSISTED REPRODUCTIVE TECHNOLOGY

Background and Aim:The vaginal microbiome is an important site of bacterial women that has continuum with microbial communities in cervical canal, uterus, fallopian tubes and peritoneal fluid. The human vaginal microbiota seem to play a key role in preventing a number of urogenital diseases, such as bacterial vaginosis, yeast infections, sexually transmitted infections, urinary tract infections , HIV infection and infectious infertility.Methods:In the past researcher analysis vaginal microbiome in culture- base method but this method have many problem such as: we cannot see all bacterial in Culture medium and.... So nowadays researcher useed 16S rRNA gene amplicon sequencing( bioinformatic method). In this method we can have a metaanalysis on all data that gained from sequencing. We have different plateform and software do analysis microbiome data with them such as QIIME or Snowman and...Results:Here، we characterized the vaginal microbiota with bioinformatic method and used QIIME and CLC software. In this study we identify some bacterial that plays key role in infertility and also and bacteria that if their concentration decreases، increase the risk of Preterm birth.Conclusion:There is a need for further exploration of the vaginal microbiota, and how the microbiota members or profile interplays with fertility or assisted reproductive technologies.

کلیدواژه ها:

female ، infertility ، microbiota ، vagina