FLUOROQUINOLONE RESISTANCE OF E.COLI ISOLATED FROM PATIENTS WITH URINARY TRACT INFECTION IN INTENSIVE CARE UNIT IN IMAM KHOMEINI HOSPITAL, SARAB, IRAN

Background and Aim:Urinary tract infection(UTI)is one of the most prevalent infectious diseases and Escherichia coli is its common cause.The rate of antimicrobial resistance in the ICU is several folds higher than in the general hospital setting. ICU is one of potential sources of nosocomial infections even in countries where extensive infection control measures are routinely implemented.This study was carried out to evaluate antimicrobial susceptibility patterns of E.coli isolated from patients with Urinary tract infection against Fluoroquinolones in intensive care unit in Imam Khomeini hospital,Sarab,IranMethods:A total of 100 E.coli isolates from 134 patients with UTI were collected. All of the isolates were identified with routine laboratory methods. Antimicrobial susceptibility pattern of isolated strains were tested by Disk Agar Diffusion (DAD) method according to CLSI standard patterns.Results:According to the results of our study 37% of isolated serotypes were sensitive to Nalidixic acid, 67% of them sensitive to Norfloxacin, 70% sensitive to Ciprofloxacin and 75% were sensitive to Ofloxacin. Also 1% of isolates showed intermediate sensitivity to Ciprofloxacin and 3% of isolates showed intermediate sensitivity to Ofloxacin according to CLSI standard protocol.Conclusion:Our results revealed a high level resistance against Fluroquinolons. It seems that this increasing trend is because of inappropriate antibiotic use. To overcome to this problem the use of unnessesary antibiotic therapy should be limited and use of various antibiotics should bu restricted to the results of antibiotic sensitivity patterns.

کلیدواژه ها:

antibiotic resistance ، Escherichia coli ، Urinary Tract Infection ، Fluroquinolon ، Sarab