URINARY TRACT INFECTION CAUSED BY EXTENDED-SPECTRUM BETA-LACTAMASE–PRODUCING BACTERIA AND INTEGRONS

سال انتشار: 1397
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 305

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شناسه ملی سند علمی:

MEDISM19_265

تاریخ نمایه سازی: 13 مهر 1397

چکیده مقاله:

Background and Aim:Urinary tract infection (UTI) is one the most common type of bacterial infections worldwide. Generally, Escherichia coli is the most frequent Gram-negative bacteria causative of UTI (70-95%) and one of the most commonly isolated organisms in clinical microbiology laboratories. For the clinical treatment of Escherichia coli, drugs such as β-lactam and quinolone are commonly used but nowadays antimicrobial resistance (AMR) is a serious global public health issue worldwide. Lateral gene transfer (LGT) and Extended-spectrum β-lactamases (ESBLs) cause antimicrobial resistance (Class I Integrons are located on transposable plasmids are known to transfer AMR through an assortment of gene cassettes and Extended-spectrum β-lactamases (ESBLs) are also known to encode genes located on integrons and transposons.Methods:Antimicrobial susceptibility testing was performed using the disk diffusion method Which is very common and low cost than other methods. To determine whether the E. coli isolates carried integrons, the conserved regions of the int genes were amplified with the degenerate primer pair hep35-hep36.Results:Here, we characterized some of the most common loci which can play a key role in antimicrobial resistance such as SHV, TEM, CTX-M, VEB, PER, BEL-1…(The most common ESBLs) and aadA2-1, aacA4, aadA1, aadA2 ( gene cassettes).Conclusion:There is a need for further exploration of the urinary tract infection, and how the Extended-Spectrum Beta-Lactamase–Producing Bacteria and integrons cause antimicrobial resistance ( mechanism of causing antimicrobial resistance )

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نویسندگان

Hossein Hosseini

Departmant of medical microbiology, Kerman of university, Iran

Zahra Golestani

B.Sc. in Cellular & Molecular Biology, Cellular & Molecular Biology Department, Higher Education Center of Estahban