COMPARISON OF ANTIFUNGAL EFFECTS OF SPARTIUM JUNCEUM AND MELISSA OFFICINALIS HERBS EXTRACTS ON CANDIDA ALBICANS IN COMPARISON WITH THE ANTIBIOTICAL EFFECT

Background and Aim:Medicinal Plants extracts were used to suggest the use of low-risk drugs in treating diseases that involve sensitive and vulnerable mucosae such as vagina and mouth.Methods:The aqueous, methanolic, and hydroalcoholic extracts were prepared by maceration and condensed by rotary. Four concentrations of 20, 30, 40 and 50 mg/ml of extracts were used. Sabouraud dextrose agar medium was used to cultivate fungus. For the effectiveness of extracts, the agar well method was used and each effect was replicated three times.Results:Hydroalcoholic extracts of both Spartium junceum and Melissa officinalis plants had the greatest inhibitory effect on growth of Candida albicans, so that with S. junceum hydroalcoholic extract, the mean halo of lack of microbial growth was 10-12 mm, but S. junceum aqueous extract had a lower effect and the methanolic extract of S. junceum was also unaffected. With the hydroalcoholic extract of M. officinalis, the mean halo diameter of lack of microbial growth was 11.75- 14.25 mm, but the M. officinalis aqueous extract was less effective (diameter of 10.75- 13.25 mm) and the methanolic extract of M. officinalis showed the halo of lack of microbial growth of 8.75-11.25 mm. To compare, nystatin antibiotic was more effective in all cases.Conclusion:It can be concluded that if infectious diseases of the vagina and oral thrush are in the early stages, the use of the hydroalcoholic extract of M. officinalis will be more effective for disinfection. Of course, clinical trials should be done.

کلیدواژه ها:

antifungal effects ، Candida albicans