THE EFFECT OF ZN NANOPARTICLES (ZNNPS) ON CIPROFLOXACIN-RESISTANT STAPHYLOCOCCUS AUREUS ISOLATES FROM SKIN INFECTIONS IN QOM PROVINCE

Background and Aim:Staphylococcus aureus is one of the most important causes of bacterial skin infection in humans and its resistance to antimicrobial drugs is important. The aim of this study is to evaluate the effect of ZnNPs on ciprofloxacin-resistant Staphylococcus aureus strains isolated from skin infections in Qom Province.Methods:To this end, 187 Staphylococcus aureus strains from skin infection samples in Qom province were identified in genotypic and phenotypic manner using different biochemical methods. The antimicrobial effects of the compounds were measured by disc diffusion and MIC methods according to the CLSI protocol.Results:Of 187 strains isolated by phenotypic methods, 165 strains (88.2%) were diagnosed as Staphylococcus aureus, of which 50 (30.3%) were resistant to ciprofloxacin by disc diffusion method and MIC microdilution was done on them. The highest concentration of inhibitor in 24 strains (48%) was obtained at 256 μg / ml during microdilution. Zn nanoparticles alone did not have an effect on Staphylococcus aureus growth inhibition, but in microdilution with ciprofloxacin in the presence of nanoparticles, the minimum growth inhibition concentration of strains was half that of Nano-free MIC.Conclusion:With the use of zinc nanostructures, the dose of ciprofloxacin used in the treatment of Staphylococcus aureus can be reduced which leads to the reduction of resistance to ciprofloxacin.