RESISTANCE RATE TO TETRACYCLINE AND RELEVANT RESISTANCE GENES, TETA, TETB, TETC AND TETD IN E.COLI ISOLATES FROM AZERBAIJAN

Background and Aim:Background: Escherichia coli isolates are commonly found in the gastrointestinal tract of animals and humans, and also be implicated in infectious diseases. Resistance to various antibiotic classes is widespread in E.coli isolated from animals and humans and may compromise treatment efficacy in tetracyclines.Methods:Materials and methods: The disc diffusion agar (DDA) was used for evaluate of tetracycline susceptibility patterns. To detect four tetracycline resistance genes (tetA, tetB, tetC, tetD,), the PCR was performed in tetracycline resistant isolates.Results:Results: In the present study, a total of 180 non-duplicated E.coli isolates were obtained from internal, pediatrics and the burn wards. Tetracycline resistance rate in target isolates were 117(65%). The Susceptible rate in E. coli isolates were as follow: 63 (35%). The rate of tet genes was found to be tetA (24.78%), tetB (31.62%), tetC (1.70%), and tetD (4.27%).Conclusion:There is an increasing rate of tetracycline resistance among E. coli isolates in Azerbaijan. The tet genes family especially tetA and tetB were prevalent among tetracycline resistant isolates. Resistance to antibiotics has become a serious problem for the medical community and has an increased effect on patients, doctors and even the community. Studies at clinical centers largely show that antibiotics are taking longer to be effective and cause the extended hospitalization of the patients, contribute to the increase in mortality rates and are a heavy financial burden.

کلیدواژه ها:

E. coli ، Tetracycline ، tet genes