Sustained Delivery of Low Mw Drugs from Thermosensitive Chitosan/GP/PLGA Hydrogel

A new and simple approach to provide injectable thermosensitive Chitosan/GP/PLGA hydrogel is described in this study. The Chitosan/GP solution can prolong the release of macromolecules for a few days. Nevertheless, with hydrophilic and low molecular weight drugs, the release is generally completed within 24 h. In this study, PLGA microspheres were added to the Chitosan/GP solution and their effect on release kinetics of incorporated drugs was investigated. The in vitro release profiles demonstrated controlled delivery over at least 50 hours. The release rate strongly depended on the drug loading and composition of incorporated PLGA in the chitosan solution.

کلیدواژه ها:

Chitosan ، PLGA ، Thermosensitive ، Injectable ، Hydrogel