Ketoprofen release from solid lipid nanoparticles of beeswax and carnauba wax

Solid lipid nanoparticles of beeswax and carnauba wax loaded with ketoprofen were prepared by microemulsion method using a mixture of egg lecithin and tween 80 as emulsifier. Increasing drug content from 0.5 to 1.5 (%wdrug/vsystem) resulted in an increased particle size of nanocarriers from 82 to 116 nm with no effect on the entrapment efficiency. The entrapment efficiency did not change after 45 days of sample storage. It was also found that drug release in 0.05 M phosphate buffer solution (PBS) was slower than that in 0.1 M PBS.

کلیدواژه ها:

Solid Lipid Nanoparticles ، Microemulsion ، Controlled release ، Ketoprofen