A ONE-POT MULTICOMPONENT STEREOSELECTIVE SYNTHESIS OF CYCLOPROPANE DERIVATIVES IN WATER

A one-pot stereoselective procedure for the preparation of 2-aroyl-1cyano-3 aryl cyclopropyl cyanide was achieved at room temperature. In this protocol, a multicomponent reaction of phenacyl bromide, 1,4-diazabicyclo[2.2.2]octane (DABCO), malononitrile, and benzaldehyde was proceeded in water media to form cis-cyclopropanes. The simplicity of the procedure, high-yield, stereoselectivity, and performing the reaction in water as a green solvent are the advantagous of this method.

کلیدواژه ها:

Stereoselective ، Cyclopropane ، Multicomponent reaction ، Green solvent