The three-component reaction of 2-(2-oxopropyl)isoindoline-1,3-dione with alkyl isocyanides and aromatic carboxylic acids under catalyst-free conditions in water
محل انتشار: فصلنامه ارتباطات شیمی ایران، دوره: 4، شماره: 1
سال انتشار: 1394
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 555
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شناسه ملی سند علمی:
JR_ICC-4-1_004
تاریخ نمایه سازی: 1 مرداد 1397
چکیده مقاله:
A green and convenient protocol is described for the preparation of 1-(alkylamino)-3-(1,3-dioxoisoindolin-2-yl)-2-methyl-1-oxopropan-2-yl benzoates via one-pot three-componentreaction between 2-(2-oxopropyl)isoindoline-1,3-dione, an alkyl isocyanide and an aromaticcarboxylic acid in water at room temperature. The methods used to follow the reactions are TLCand NMR, which indicated that there is no side product and the products were obtained withoutany purification. The structures of the products were deduced from their 1H NMR, 13C NMR andIR spectra. The present methodology offers several advantages such as a simple procedure,catalyst-free, mild reaction conditions, high yields, and the absence of any volatile and hazardousorganic solvents.
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نویسندگان
Ali Jafari
Department of Chemistry, University of Zanjan, P.O. BOX ۴۵۱۹۵-۳۱۳, Zanjan, Iran
Ali Ramazani
School of Mechanical Engineering, Yeungnam University, Gyeongsan ۷۱۲-۷۴۹, Republic of Korea
Sang Woo Joo
Young Researchers and Elite Clube, Marand Branch, Islamic Azad University, Marand , Iran
Yavar Ahmadi
Department of Chemistry, Payame Noor University, P.O. BOX ۱۹۳۹۵-۴۶۹۷ Tehran, Iran