Role of Tranexamic Acid in Conservative Treatment of Patientswith Epidural Hematoma

Introduction: Traumatic brain injury is considered as the major cause of mortality and hospitalization of about ten million peopleacross the globe. Most of these patients are young and active people suffering disabilities. Tranexamic acid therapy is commonlyused to reduce blood loss and need for blood transfusions in surgical cases. This study aimed at investigating the effect of tranexamicacid drug in patients with epidural hematoma.Methods & Materials/Patients: In a clinical trial study, 100 patients with acute epidural hematoma diagnosed with traumaticbrain injury were enrolled. The patients in two groups were matched for age and sex. We treated 50 patients with tranexamic aciddrug that were compared with 50 patients in the control group. Hematoma size variations (diameter and volume) between the twogroups were studied.Results: We studied 100 patients with traumatic brain injury with a mean age of 34.2 ± 7.9. Of the patients, 69% were male, and31% were female. Hematoma occurrence rate was 33%, 39%, and 28% in parietal, frontal, and temporal region, respectively.Hematoma diameter was 3.71 ± 1.8 mm after treatment with tranexamic acid, and 4.03 ± 1.6 mm in the control group. There wasno statistically significant difference between the two groups. The volume of hematoma was 8.04 ± 3.2 cc in patients treated withtranexamic acid, and 10.4 ± 3.7 cc in the control group. There was statistically significant difference between the two groups.Conclusion: According to our study, tranexamic acid drug can be effective on bleeding control in patients with acute epiduralhematoma. The role of these drugs in elective surgeries has been proven. In cases of brain trauma, they can be useful and improvethe prognosis of patients.

کلیدواژه ها:

Tranexamic Acid ، Acute Epidural Hematoma ، Brain Trauma ، Cerebral Hemorrhage