Multiple sclerosis during pregnancy and maternal, fetal, neonatal outcomes: A systematic review study

Multiple sclerosis (MS) is a chronic neurological disease which commonly affects women in childbearing agesso prompts perinatal-related issues. In this regard, present review aimed to sum up the research findings.The databases of PubMed, Scopus, Google Scholar, SID and Magiran were searched with keywords of Multiplesclerosis , Pregnancy , maternal, fetal, neonatal outcome to identify relevant articles. Included were allPersian and English articles, published between 2000 and December 2017. Out of 303 relevant articles, a total of10 studies were ultimately reviewed systematically.Based on present review, Pregnancy seems to be associated with clinical MS stability or improvement, whilepostpartum period seems to be one of high risk for clinical flares of symptoms. Some of maternal complicationswere: slightly increase in urinary tract infections, adverse delivery outcomes including instrument-assistedvaginal delivery, cesarean delivery and induction of labor. Studies on fetal outcomes have conflicting results.Some studies showed no increase risk, in opposition to; some others showed 5% spontaneous abortions, 2%stillbirths, miscarriage rate of 30%, prematurity rate of 10%, 7.69% intrauterine death and 5.80% lowbirthweight. In neonates Small for gestational age (SGA) seems to be increased. No specific long-term adverseevents were observed in the offspring of women with MS.MS does not appear to pose significant increases in adverse pregnancy outcome but have some impacts on birthprocess; fetus, neonate and postpartum flares. So providing supportive care and close follow-up throughout labor,birth, and postpartum is especially important.

کلیدواژه ها:

Multiple sclerosis ، Pregnancy ، maternal ، fetus ، neonatal outcome