Stimulation of Ovulation and The Risk of Cancer in Women

Background: The use of fertility treatment has increased considerably in recent decades.It is estimated that 10 percent of couples are seeking fertility treatment in advanced countries. Infertility treatment in any woman requires a large amount of different hormones that, based on studies, exposure to hormones, can lead to hormonal-sensitive cancers, especially endometrium, breast And ovary cancers. Therefore, this study aimed to Stimulation of ovulation and the risk of cancer in women. Materials and Methods: This review study was conducted with collect of information about the subject in resources and scientific sites. Results: The results showed that the two groups of evidence increase the concern about the effects of ovulation stimulants as risk factors for cancer. First, clomiphene citrate and gonadotropins are the most common used drugs to stimulation ovulation and incidence of breast and ovarian cancers. secondly, These drugs increase the levels of estrogen (E2) and progesterone (P) hormones that these hormones are known as affective factors in development of breast cancer and the other cancers in Women. Conclusion: According to epidemiological studies, there is a relationship between the use of fertility drugs and the increased risk of cancer in women, but no causal relationship has not been proved between fertility treatment and cancer and the results of various studies are contradictory. To investigate this subject, it is necessary to conduct of prospective cohort studies with a larger population, and a better adjustment of the confounding factors.

کلیدواژه ها:

Infertility ، Ovulation stimulation ، Female cancer ، Infertility drugs