Anti-Inflammatory Action of Gamma (Γ)-Irradiated Genistein on Ovary Tissue Modification in Polycystic Ovary Syndrome

Background: Radiation has long been applied in the various fields, such as sterilization of medical supplies and food components and increases the antioxidant activity of bioactive materials. Genistein is well known as a bio-functional material that is present in soybean, and associate with prevention and therapy of various diseases,such as inflammation and oxidative damage. According to Rotterdam criteria, about 15.2 % of Iranian women suffer PCOS. Studies suggest that oxidative stress could be concern in pathobiology of this incident disorder. Methods: In this study the syndrome induced by muscular injection of 40 mg/kg Estradiol Valerate to 24 female Wistar rats, weighing 170-180 g. Control group receive no injection. After 60 days the animals divided to control, PCOS and PCOS treated with irradiated genistein (2 and 5 mg/kg) groups. After 21 days interperitoneal treatment of irradiated genistein, the ovaries of all groups histologically studied. Results and Discussion: There was a signification polycystic improvement in ovaries treated with high concentration of irradiated genistein in comparison with PCOs group and also granulosa layer increase, thickness of the theca layer decrease, reduction of cystic follicular number and corpus luteum increase were found, that could be a sign of renewed ovulation. Conclusion: irradiated genistein could decrease PCOS histological signs that lead to ovulation rate reduction, and have reparation effects on ovary tissue. It is possible that, this ability is because of irradiated genistein antioxidant and antiinflammatory effects that motivate reduction of cysts number and natural development of follicles.

کلیدواژه ها:

γ-irradiated genistein ، Polycystic ovary ، Infertility